Selected Publications

Kurabayashi N, Tanaka A, Nguyen MD & Sanada K. The LPA-LPA4-Filamin A axis is required for establishment of bipolar morphology and radial migration of newborn cortical neurons. Development, Sep 14;145(17). pii: dev162529. doi: 10.1242/dev.162529 (2018). 


Hong J-H, Kwak Y-D, Woo Y-S, Park C, Lee S-A, Sanada K, Nguyen MD & Park SK. Regulation of the actin cytoskeleton by the Ndel1-Tara complex is critical for cell migration and invasion. Scientific Reports, doi: 10.1038/srep31827 (2016). 


Jiang Y, Gavrilovici C, Chansard M, Liu RH, Ivana K, Parsons K, Park SK, Teskey CG, Rho JM & Nguyen MD. Ndel1 co-operates with Reelin to maintain postnatal CA1 hippocampus integrity. Journal of Neuroscience, 36 (24): 6538-52 (2016). 


Kurabayashi N, Nguyen MD, & Sanada K. DYRK1A overexpression enhances STAT activity and astrogliogenesis in a mouse model of Down’s syndrome. EMBO Reports, pii: e201540374 (2015). 


Shim SY, Castro-Perez I, Neumayer G, Wang J, Park SK, Sanada K & Nguyen MD. Phosphorylation of Targeting Protein for Xenopus kinesin-like protein 2 (TPX2) at threonine 72 in spindle assembly. Journal of Biological Chemistry, 290: 9122-34 (2015). 


Parsons K, Yoshihiro Nakatani & Nguyen MD. p600 / UBR4 in the central nervous system. Cellular and Molecular Life Sciences, 72: 1149-60 (2015) 


Neumayer G & Nguyen MD. TPX2 impacts acetylation of Histone H4 at lysine 16: Implications for DNA damage response. PLOS ONE, Nov 3;9(11):e110994. doi: 10.1371/journal.pone.0110994. eCollection (2014). 


Belzil C, Asada N, Ishiguro K, Nakaya T, Parsons K, Pendolino V, Neumayer G, Mapelli M, Nakatani Y, Sanada S & Nguyen MD. p600 regulates spindle orientation in apical neural progenitors and contributes to neurogenesis in the developing neocortex. Biology Open 3:475-85 (2014). 


Neumayer G, Belzil C, Gruss O & Nguyen MD. TPX2: Of spindle assembly, DNA damage response and cancer. Cellular and Molecular Life Sciences, 71:3027-47 (2014). Cover of the July issue.   


Kurabayashi N, Nguyen MD, & Sanada K. GPRC5B, a G protein-coupled receptor, contributes to neurogenesis in the developing neocortex. Development, 140: 4335-46 (2013). 


Belzil C, Neumayer G, Vassilev AP, Yap KL, Konishi H, Rivest S, Sanada S, Ikura M, Nakatani Y & Nguyen MD. A Ca2+-dependent mechanism of neuronal survival mediated by the microtubule- associated protein p600. Journal of Biological Chemistry, 288: 24452-64 (2013). 


Tasaki T, Kim ST, Zakrzewska A, Lee BE, Kang MJ, Yoo YD, Cha-Molstad HJ, Hwang J, Soung NK, Sung KS, Kim SH, Nguyen MD, Sun M, Yi EC, BY Kim & Kwon YT. UBR4, a N-recognin of the the N-end rule pathway, and its role in yolk sac vascular development and autophagy. Proc Natl Acad Sci USA, 110: 3800-5 (2013). 


Neumayer G, Helfricht A, Shim S, Le Thi H, Lundin C, Belzil C, Chansard M, Gruss O, Lees Miller SP, van Attikum H, Helleday T & Nguyen MD. Targeting Protein for Xenopus kinesin-like protein 2 (TPX2) regulates gamma-H2AX levels upon ionizing radiation. Journal of Biological Chemistry, 287: 42206-42222 (2012). 

> featured at 


Chansard M, Hong J-H, Park Y-U, Park SK & Nguyen MD. Ndel1, Nudel (noodle): Flexible in the Cell? Cytoskeleton, 68:540-54 (2011). 


Chansard M, Wang J, Tran HC, Neumayer G, Shim SY, Park YU, Belzil C, Le Thi H, Park SK & Nguyen MD. The cytoskeletal protein Ndel1 regulates Dyn2 GTPase activity. PLOS ONE, 6:e14583 (2011). 


Park YU, Lee H, Jeong J , Young Mun J, Kim JH, Lee JS, Nguyen MD, Han SS, Suh PG & Park SK. Disrupted-in-schizophrenia 1 (DISC1) plays essential roles in mitochondria in collaboration with Mitofilin. Proc Natl Acad Sci USA 107: 17785-90 (2010). 


Shim S, Wang J, Asada N, Neumayer G, Tran HC, Ishiguro K, Sanada K, Nakatani Y & Nguyen MD. P600 is a Microtubule / Endoplasmic Reticulum - Associated Protein in CNS Neurons. Journal of Neuroscience 28: 3604-3614 (2008). 


Shim S, Samuels BA*, Wang J*, Neumayer G, Belzil C, Ayala R, Shi Y, Shi Y, Tsai LH & Nguyen MD. Ndel1 controls the Dynein-mediated transport of Vimentin during neurite outgrowth. Journal of Biological Chemistry 283:12232-4 (2008). *These authors contributed equally to this work 


Kim D*, Nguyen MD*, Fischer A, Sanabenesi F, Dobbins M, Rodgers JT, Dellale I, Sui G, Baur JA, Armour S, Puigserver P, JA, Sinclair DA & Tsai LH. SIRT1 deacetylase protects against neurodegeneration in mouse models of Alzheimer’s disease and Amyotrophic Lateral Sclerosis. EMBO Journal. 26: 3169-3179 (2007). *These authors contributed equally to this work 

> One the 10 most-read EMBO papers online in July 2007 


Park SK, Nguyen MD*, Fisher A*, Luke MP, Affar EB, Dieffenback P, Tseng HC, Shi Y & Tsai LH. Prostate apoptosis response 4 links dopamine signaling and depression. Cell 122: 275-287 (2005) *These authors contributed equally to this work 

> Previewed in Cell, p153-155 (2005), Cover of the July Issue 

> Commented in Neuron, Vol 47, 335-338 (2005) 

> Science STKE Editor choice, 295: tw 277  

> Commented in Psychiatry Dispatches in Primary Psychiatry, 12: 12-23  


Shu T, Ayala R*, Nguyen MD*, Xie Z, Gleeson J & Tsai LH. Ndel1 Operates in a Common Pathway with LIS1 and Cytoplasmic Dynein to Regulate Cortical Neuronal Positioning. Neuron 44: 263-277 (2004). *These authors contributed equally to this work   

> Previewed in Neuron, p213-214.   


Nguyen MD#, Shu T, Sanada K, Larivière RC, Tseng HC, Park SK, Julien JP & Tsai LH#. A NUDEL-dependent mechanism of Neurofilaments assembly regulates the integrity of CNS neurons. Nature Cell Biology 6: 595-608 (2004). (# co-corresponding authors) 

> Full article highlighted by Nature Cell Biology in the News and Views section, p.569-570,  

> Cover of the July issue.  

> Photographs of the publication reproduced by the Human Frontier Science Program    

   Organization and by Amaxa Biosystems for artistic and scientific purposes 


Nguyen MD, D’aigle T, Gowing G, Julien JP & Rivest S. Exacerbation of motor neuron disease by a chronic stimulation of innate immunity in a mouse model of ALS, Journal of Neuroscience 24:1340-1349 (2004). 


Clement AM, Nguyen MD, Roberts EA, Garcia ML, Boillée S, Rule M, McMahon AP, Doucette W, Siwek D, Ferrante RJ, Brown Jr RH, Julien JP, Goldstein LSB & Cleveland DW. Wild-Type Nonneuronal Cells Extend Survival of SOD1 Mutant Motor Neurons in ALS Mice. Science 302: 113-117 (2003).  

> Commented in Nature Medicine 10, 224-225 (2004). 


Nguyen MD, Mushynski WE & Julien JP. Cycling at the interface between neurodevelopment and neurodegeneration. Cell Death & Differentiation 9: 1294-1306 (2002). Review. 


Nguyen MD, Julien JP & Rivest S. Innate Immunity: The missing Link in Neuroprotection and Neurodegeneration?  Nature Reviews Neuroscience 3: 216-227 (2002). Review. 


Nguyen MD, Julien JP & Rivest S. Induction of Proinflammatory Molecules in ALS Mice: No Requirement for Proapoptotic IL-1 alpha in Neurodegeneration. Annals of Neurology 50: 630-639 (2001). 


Nguyen MD, Larivière RC & Julien JP. Deregulation of Cdk5 activity in a mouse model of ALS: Toxicity alleviated by perikaryal neurofilament inclusions. Neuron 30: 135-147 (2001).  

> Commented in Trends in Neurosciences 25, 8-10 (2002). 

> One the 10 most-read Neuron papers online in May and June 2001 


Nguyen MD, Larivière RC & Julien JP. Reduction of axonal caliber does not alleviate motor neuron disease caused by mutant superoxide dismutase 1. Proc. Natl. Acad. Sci. USA 97: 12306-12311 (2000).