Selected Publications
Mun DJ, Goo BS, Suh BK, Hong JH, Lee SB, Woo Y, Kim S, Kim SJ, Won Y, Yoo JY, Cho E, Jang EJ , Lee H, Nguyen MD, Baek ST, Park SK. Gcap14 is a novel microtubule plus-end-tracking protein coordinating microtubule-actin crosstalk during neurodevelopment. Proc Natl Acad Sci USA, doi: 10.1073/pnas.2214507120.
Institoris A, Vandal M, Peringod G, Tran CH, Yu X, Breitener C, Molina L, Khakh BS, Nguyen MD, Thompson RJ & Gordon GR. Astrocytes amplify cerebral blood flow to sustain cortical activation in the awake mouse. Nature Communications, doi: 10.1038/s41467-022-35383-2 (2022).
Haidey JN, Peringod G, Institoris A, Gorzo KA, Nicola W, Vandal M, Ito K, Liu S, Fielding C, Visser F, Nguyen MD and Gordon GR. Ultra-slow regulation of arteriole oscillations by astrocytes via stretch-mediated TRPV4-COX1 feedback. Cell Reports, doi: 10.1016/j.celrep.2021.109405 (2021)
Gavrilovici C*, Jiang Y*, Kiroski I, Sterley TL, Vandal M, Bains JS, SK Park, JM Rho, Teskey GC & Nguyen MD. Behavioral deficits in mice with postnatal disruption of Ndel1 in forebrain excitatory neurons: Implication for epilepsy and neuropsychiatric disorders. Cerebral Cortex Communications, doi: 10.1093/texcom/tgaa096 (2021) *These authors contributed equally to this work
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Hoghooghi V, Palmer AL, Frederick A, Jiang Y, Merkens JE, Balakrishnan A, Finlay TM, Grubb A, Levy E, Gordon P, Jirik F, Nguyen MD, Schuurmans C, Visser F, Dunn SE and Ousman SS. Cystatin C Plays a Sex-Dependent Detrimental Role in MOG35-55-Induced Experimental Autoimmune Encephalomyelitis. Cell Reports, doi: 10.1016/j.celrep.2020.108236 (2020).
Gavrilovici C, Jiang Y, Kiroski I, Teskey GC, Rho JM & Nguyen MD. Postnatal role of the cytoskeleton in adult epileptogenesis. Cerebral Cortex Communications, Feature Article, 1(1):tgaa024. doi: 10.1093/texcom/tgaa024 (2020).
Naito Y, Asada N, Nguyen MD and Sanada K. AMP-activated protein kinase regulates cytoplasmic dynein behavior and contributes to neuronal migration in the developing neocortex. Development, 147(14):dev187310. doi: 10.1242/dev.187310 (2020)
Kiroski I*, Jiang Y*, Gavrilovici C*, Gao F, Lee S, Scantlebury M, Vandal M, Park SK, Tsai LH, Teskey GC, Rho JM & Nguyen MD. Reelin improves cognition and extends the lifespan of mutant Ndel1 mice with postnatal CA1 hippocampus deterioration *These authors contributed equally to this work. Cerebral Cortex, 30(9):4964-4978. doi: 10.1093/cercor/bhaa088 (2020). Cover of the September issue.
Woo Y, Kim SJ, Suh BK, Mun DJ, Truong NTM, Kim S, Noh S-J, Kwak Y, Hong J-H, Jung H-J, Baek ST, Nguyen MD, Choe Y and Park SK. Sequential phosphorylation of NDEL1 by the TARA-DYRK2-GSK3β complex regulates neuronal morphogenesis. ELife, 8. pii: e50850. doi: 10.7554/eLife.50850 (2019).
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Kurabayashi N, Tanaka A, Nguyen MD & Sanada K. The LPA-LPA4-Filamin A axis is required for establishment of bipolar morphology and radial migration of newborn cortical neurons. Development, Sep 14;145(17). pii: dev162529. doi: 10.1242/dev.162529 (2018).
Hong J-H, Kwak Y-D, Woo Y-S, Park C, Lee S-A, Sanada K, Nguyen MD & Park SK. Regulation of the actin cytoskeleton by the Ndel1-Tara complex is critical for cell migration and invasion. Scientific Reports, doi: 10.1038/srep31827 (2016).
Jiang Y, Gavrilovici C, Chansard M, Liu RH, Ivana K, Parsons K, Park SK, Teskey CG, Rho JM & Nguyen MD. Ndel1 co-operates with Reelin to maintain postnatal CA1 hippocampus integrity. Journal of Neuroscience, 36 (24): 6538-52 (2016).
Kurabayashi N, Nguyen MD, & Sanada K. DYRK1A overexpression enhances STAT activity and astrogliogenesis in a mouse model of Down’s syndrome. EMBO Reports, pii: e201540374 (2015).
Shim SY, Castro-Perez I, Neumayer G, Wang J, Park SK, Sanada K & Nguyen MD. Phosphorylation of Targeting Protein for Xenopus kinesin-like protein 2 (TPX2) at threonine 72 in spindle assembly. Journal of Biological Chemistry, 290: 9122-34 (2015).
> Mentioned in "SnapShot: Phosphoregulation of Mitosis" by Cell journal. See https://www.ncbi.nlm.nih.gov/pubmed/28622516
Parsons K, Yoshihiro Nakatani & Nguyen MD. p600 / UBR4 in the central nervous system. Cellular and Molecular Life Sciences, 72: 1149-60 (2015)
Neumayer G & Nguyen MD. TPX2 impacts acetylation of Histone H4 at lysine 16: Implications for DNA damage response. PLOS ONE, Nov 3;9(11):e110994. doi: 10.1371/journal.pone.0110994. eCollection (2014).
Belzil C, Asada N, Ishiguro K, Nakaya T, Parsons K, Pendolino V, Neumayer G, Mapelli M, Nakatani Y, Sanada S & Nguyen MD. p600 regulates spindle orientation in apical neural progenitors and contributes to neurogenesis in the developing neocortex. Biology Open 3:475-85 (2014).
Neumayer G, Belzil C, Gruss O & Nguyen MD. TPX2: Of spindle assembly, DNA damage response and cancer. Cellular and Molecular Life Sciences, 71:3027-47 (2014). Cover of the July issue.
Kurabayashi N, Nguyen MD, & Sanada K. GPRC5B, a G protein-coupled receptor, contributes to neurogenesis in the developing neocortex. Development, 140: 4335-46 (2013).
Belzil C, Neumayer G, Vassilev AP, Yap KL, Konishi H, Rivest S, Sanada S, Ikura M, Nakatani Y & Nguyen MD. A Ca2+-dependent mechanism of neuronal survival mediated by the microtubule- associated protein p600. Journal of Biological Chemistry, 288: 24452-64 (2013).
Tasaki T, Kim ST, Zakrzewska A, Lee BE, Kang MJ, Yoo YD, Cha-Molstad HJ, Hwang J, Soung NK, Sung KS, Kim SH, Nguyen MD, Sun M, Yi EC, BY Kim & Kwon YT. UBR4, a N-recognin of the the N-end rule pathway, and its role in yolk sac vascular development and autophagy. Proc Natl Acad Sci USA, 110: 3800-5 (2013).
Neumayer G, Helfricht A, Shim S, Le Thi H, Lundin C, Belzil C, Chansard M, Gruss O, Lees Miller SP, van Attikum H, Helleday T & Nguyen MD. Targeting Protein for Xenopus kinesin-like protein 2 (TPX2) regulates gamma-H2AX levels upon ionizing radiation. Journal of Biological Chemistry, 287: 42206-42222 (2012).
Chansard M, Hong J-H, Park Y-U, Park SK & Nguyen MD. Ndel1, Nudel (noodle): Flexible in the Cell? Cytoskeleton, 68:540-54 (2011).
Chansard M, Wang J, Tran HC, Neumayer G, Shim SY, Park YU, Belzil C, Le Thi H, Park SK & Nguyen MD. The cytoskeletal protein Ndel1 regulates Dyn2 GTPase activity. PLOS ONE, 6:e14583 (2011).
Park YU, Lee H, Jeong J , Young Mun J, Kim JH, Lee JS, Nguyen MD, Han SS, Suh PG & Park SK. Disrupted-in-schizophrenia 1 (DISC1) plays essential roles in mitochondria in collaboration with Mitofilin. Proc Natl Acad Sci USA 107: 17785-90 (2010).
Shim S, Wang J, Asada N, Neumayer G, Tran HC, Ishiguro K, Sanada K, Nakatani Y & Nguyen MD. P600 is a Microtubule / Endoplasmic Reticulum - Associated Protein in CNS Neurons. Journal of Neuroscience 28: 3604-3614 (2008).
Shim S, Samuels BA*, Wang J*, Neumayer G, Belzil C, Ayala R, Shi Y, Shi Y, Tsai LH & Nguyen MD. Ndel1 controls the Dynein-mediated transport of Vimentin during neurite outgrowth. Journal of Biological Chemistry 283:12232-4 (2008). *These authors contributed equally to this work
Kim D*, Nguyen MD*, Fischer A, Sanabenesi F, Dobbins M, Rodgers JT, Dellale I, Sui G, Baur JA, Armour S, Puigserver P, JA, Sinclair DA & Tsai LH. SIRT1 deacetylase protects against neurodegeneration in mouse models of Alzheimer’s disease and Amyotrophic Lateral Sclerosis. EMBO Journal. 26: 3169-3179 (2007). *These authors contributed equally to this work
> One the 10 most-read EMBO papers online in July 2007
Park SK, Nguyen MD*, Fisher A*, Luke MP, Affar EB, Dieffenback P, Tseng HC, Shi Y & Tsai LH. Prostate apoptosis response 4 links dopamine signaling and depression. Cell 122: 275-287 (2005) *These authors contributed equally to this work
> Previewed in Cell, p153-155 (2005)
> Cover of the July Issue
> Commented in Neuron, Vol 47, 335-338 (2005)
> Science STKE Editor choice, 295: tw 277
> Commented in Psychiatry Dispatches in Primary Psychiatry, 12: 12-23
Shu T, Ayala R*, Nguyen MD*, Xie Z, Gleeson J & Tsai LH. Ndel1 Operates in a Common Pathway with LIS1 and Cytoplasmic Dynein to Regulate Cortical Neuronal Positioning. Neuron 44: 263-277 (2004). *These authors contributed equally to this work
> Previewed in Neuron, p213-214
Nguyen MD#, Shu T, Sanada K, Larivière RC, Tseng HC, Park SK, Julien JP & Tsai LH#. A NUDEL-dependent mechanism of Neurofilaments assembly regulates the integrity of CNS neurons. Nature Cell Biology 6: 595-608 (2004). (# co-corresponding authors)
> Full article highlighted by Nature Cell Biology in the News and Views section, p.569-570
> Cover of the July issue.
> Photographs of the publication reproduced by the Human Frontier Science Program Organization and by Amaxa
Biosystems for artistic and scientific purposes
Nguyen MD, D’aigle T, Gowing G, Julien JP & Rivest S. Exacerbation of motor neuron disease by a chronic stimulation of innate immunity in a mouse model of ALS, Journal of Neuroscience 24:1340-1349 (2004).
Clement AM, Nguyen MD, Roberts EA, Garcia ML, Boillée S, Rule M, McMahon AP, Doucette W, Siwek D, Ferrante RJ, Brown Jr RH, Julien JP, Goldstein LSB & Cleveland DW. Wild-Type Nonneuronal Cells Extend Survival of SOD1 Mutant Motor Neurons in ALS Mice. Science 302: 113-117 (2003).
> Commented in Nature Medicine 10, 224-225 (2004)
Nguyen MD, Mushynski WE & Julien JP. Cycling at the interface between neurodevelopment and neurodegeneration. Cell Death & Differentiation 9: 1294-1306 (2002). Review.
Nguyen MD, Julien JP & Rivest S. Innate Immunity: The missing Link in Neuroprotection and Neurodegeneration? Nature Reviews Neuroscience 3: 216-227 (2002). Review.
Nguyen MD, Julien JP & Rivest S. Induction of Proinflammatory Molecules in ALS Mice: No Requirement for Proapoptotic IL-1 alpha in Neurodegeneration. Annals of Neurology 50: 630-639 (2001).
Nguyen MD, Larivière RC & Julien JP. Deregulation of Cdk5 activity in a mouse model of ALS: Toxicity alleviated by perikaryal neurofilament inclusions. Neuron 30: 135-147 (2001).
> Commented in Trends in Neurosciences 25, 8-10 (2002).
> One the 10 most-read Neuron papers online in May and June 2001
Nguyen MD, Larivière RC & Julien JP. Reduction of axonal caliber does not alleviate motor neuron disease caused by mutant superoxide dismutase 1. Proc. Natl. Acad. Sci. USA 97: 12306-12311 (2000).
